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pentobarbital improves toxicity of methoxyflurane by escalating metabolism. Contraindicated. Improved metabolism of methoxyflurane to nephrotoxic compounds.Monitor Closely (two)pentobarbital will decrease the extent or influence of suvorexant by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check. Sturdy CYP3A4 inducers may p